![]() RFLP analysis has been widely employed by researchers to identify genes linked to several Mendelian (single-gene) diseases, such as Huntington's disease. The oldest method used in DNA fingerprinting studies is restriction fragment length polymorphism ( RFLP) analysis. ![]() In contrast, other techniques are concerned with dominant markers, which only report the presence or absence of a given allele and cannot provide information about whether an individual is homozygous for that allele. Some approaches focus on codominant markers, which provide information about both alleles present at a given locus. For example, some approaches allow the examination of a marker at a single locus (called single-locus markers), whereas others allow the simultaneous investigation of multiple loci (called multilocus markers). Researchers choose among these techniques based on the organism being studied and on the question being addressed.Īll DNA fingerprinting methods study patterns associated with genetic markers however, individual techniques differ in terms of the number and type of genetic markers examined. ![]() A wide range of techniques can be used to generate DNA fingerprinting data. In order to understand how AFLP-PCR works, it's first important to understand what researchers mean when they use the term " DNA fingerprinting." In short, DNA fingerprinting involves the generation of a set of distinct DNA fragments from a single DNA sample these fragments are then used as a source of genotypic information.
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